Personally, I use acrylics because that's what my father taught me to use. We have a restored Bally Bingo "Miami Beach" which was done 10-12 years ago and it looks exactly as it was the day we repainted it. There's no problem with using enamels - it is whatever you are comfortable using, I've never used 2-pac paints, so I really don't know the pros and cons. I just love working with acrylics as that's what works for me.